Osteoporosis : Current Management strategies

table 1 : World Health organisation criterion for the diagnosis of osteoporosis, 1994 category definition by bone mineral density t-score Normal A value for BMD that is not more than 1 SD below the young adult mean value ≥-1 Osteopenia A value for BMD that lies between 1 and 2.5 SD below the young adult mean value -1 to -2.5 Osteoporosis A value for BMD that is more than 2.5 SD below the young adult mean value ≤ -2.5 Established A value for BMD more than 2.5 SD below osteoporosis the young adult mean value in the presence of one or more fragility fractures ≤ -2.5 + presence of one or more fractures Resorption – Activated lining cells along with osteoblastic precursors secrete RANKL (receptor activator of nuclear factor kappa B) which along with M-CSF (macrophage colony stimulating factor), NFkB (nuclear factor kappa B) and c-fos promotes differentiation and activation of committed precursors to mature osteoclasts. These produce bone resorption.